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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AICD: activation-induced cell death AIF: apoptosis-inducing factor BSO: L-buthionine-( S,R )-sulfoxime CD95-L: CD95 ligand CD95: CD95 receptor DISC: death-inducing signaling complex Doxo: doxorubicin m: mitochondrial membrane potential FADD: Fas-associated death domain FSC: forward scatter GSH: glutathione NGF: nerve growth factor PARP: poly(ADP-ribose)polymerase PFA: paraformaldehyde PI: propidium iodide PMSF: phenyl methyl sulfonyl fluoride PT: permeability transition ROS: reactive oxygen species SSC: side scatter TNF: tumor necrosis factor XIAP: X-linked inhibitor-of-apoptosis protein References Kaufmann SH and Earnshaw WC (2000) Induction of apoptosis by cancer therapy

Bei et al., showed that the specific ROCK inhibitor Fasudil suppressed hypochlorous acid dermal fibrosis in mice by inhibiting TGF- downstream signaling proteins Smad2/3 and ERK1/2 [131]

Symptoms have occurred at MetHb levels ranging from 1.9% to 26.8%, mostly at the 100-mg dose

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