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Additional findings that emerged included positive associations with some cancers of the lymphatic system or tissue (NHS and HPFS studies, assessing artificially sweetened beverages and tabletop sweeteners containing aspartame), as well as pancreatic cancer (CPS-II and EPIC studies, using baseline consumption of artificially sweetened beverages)

651,652 Similarly, CR-boosted NAD + level protects the brain against aging and diseases through attenuating plasma membrane lipid peroxidation, protein carbonyls, nitrotyrosine and oxidative stress