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BPC-157 upregulates VEGFR2 expression in vascular endothelial cells at both mRNA and protein levels without increasing VEGF-A production, suggesting the peptide sensitizes endothelial cells to existing VEGF rather than simply increasing ligand availability

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Second, unlike full-length growth hormone, AOD-9604 does not bind to growth hormone receptors present throughout the body

22 It is speculated that fibrin deposition with thrombus formation on the damaged vessel wall occurs through modification of the electrostatic charge of the endothelial cells