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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

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Similar to CD4 + T cells, in which LDHA is induced by TCR stimulation [108], antigen-specific CD8 + T cells also upregulate the expression of LDHA upon activation [181]

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