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DC32, a dihydroartemisinin derivative, ameliorates collagen-induced arthritis through an Nrf2-p62-Keap1 feedback loop

Overproduction of ROS triggers inflammatory responses, prominently involving the nuclear factor kappa-B (NF-B) pathway, a key regulator of inflammation (84, 85)

Done well, that supports your own biology rather than overriding it

Omar HA, Tolba MF (2018) Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: role of IGF-1R/protein kinase-B (Akt)/-catenin signaling