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In general, the dysbiotic gut microbiota significantly disrupts the intricate equilibrium between the generation of ROS and the process of detoxification, thereby contributing to both DNA damage and the development of intestinal diseases (Figure 2)

Moreover, within the One Health framework, which emphasizes the interconnected well-being of all living organisms within ecosystems (Mackenzie and Jeggo 2019), NAC holds significant promise

Reduced Glutathione (GSH) 5.4.1.1.2

The oxidative stress-inducible cystine/glutamate antiporter, system x c : cystine supplier and beyond

By increasing the levels of these neurotransmitters, SAMe can help reduce pain perception [69]