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In hypoxia, the activity of PHDs is restricted, and HIF- dimerizes with HIF-1 to form transcriptionally active complexes capable of binding with high affinity to DNA sequences at hypoxia response elements (HREs) and thus modulating gene transcription

Thymosin also slows the death of cells, reduces inflammation, increases cell proliferation, and stimulates hair growth, amongst a host of other effects

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The ASAP score [HR 1.19 (95%CI 1.05-1.35), p=0.006] was the only independent predictor of recurrence in a multivariable model including only scores and algorithms