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Psychiatry 95 LavalL.MartinR.NatividadJ

Oxidative stress is associated with excess copper ions, while copper ion deficiency affects the association between copper and the mitochondria, as well as copper and vascular regulation (36)

The hippocampus displays microglial activation, elevated IL-6 and tumor necrosis factor alpha (TNF-), as well as neurotrophic factor signaling disturbances in APP1/PS1 mice with anxiety-like phenotypes (Gao et al., 2018)