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Moreover, as the health-promoting attributes of plant-based diets are derived from biometabolites like polyphenols, probably, massive protein extraction and food processing can substantially influence their occurrence, along with other bioactivities (Toh et al., 2022)

The protective effect of HO-1 in diabetic retinopathy is not only reflected in the inhibition of inflammation and oxidative stress but also promoted microglia polarization from the M1 state (pro-inflammatory) towards the M2 state (anti-inflammatory) [159]