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[15] shows that hypertension can be introduced in Wistar rats by oral administration N G -nitro-l-arginine methyl ester (l-NAME), which significantly inhibited CSE expression and H 2 S synthesis in the thoracic aorta

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Suggested Titration Protocol Suggested peptide titration protocol: Start with 100 mcg of each peptide daily by subcutaneous injection , then increase the dose by around 50 mcg every 12 weeks as tolerated