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Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum

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Small-molecule inhibitors such as Brusatol (though its effects extend beyond NRF2, including global inhibition of protein synthesis) and ML385 have demonstrated efficacy in preclinical studies by suppressing NRF2-driven transcription and re-sensitizing tumors to chemotherapy and radiotherapy ( Figure 4 ) ( Given the hormonal regulation of NRF2 in estrogen-responsive cancers, rational drug combinations are gaining attention