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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease

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If youre deficient in Vitamin B12, supplementation is important

We believe this is appropriate because testing shows differences in observed episode costs among STEMI, non-STEMI, and other inpatient PCI episodes are neutralized via sub-grouping and risk adjustment

In the book, Attia distinguishes between standard medical thinking, what he calls Medicine 2.0, and his approach, Medicine 3.0