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Statistical Analyses Statistical analyses were performed using GraphPad Prism (San Diego, CA, USA)

doi: 10.1111/j.1479-828X.2007.00723.x 219 XuYNisenblatVLuCLiRQiaoJZhenXet al

doi: 10.1016/j.jfma.2017.09.006

10.1038/s41579-022-00681-5 280 LiuJ.LiuC.YueJ

Further research remains warranted to address unanswered questions, such as whether DN results from global metabolic reprogramming of the PNS and how energy transfer or toxic byproducts between nerve cells contribute to the disease