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Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers

In aggregate, a two-pronged paradigm is emerging: redesign cytotoxics to narrow their biodistribution, and concurrently deploy small-molecule fertoprotectants that intercept DNA damage, oxidative stress or apoptotic checkpoints specifically within the ovary

Interestingly, higher occurrence rates were mostly reported in studies applying ELISA compared to HPLC analyses

Furthermore, NCOA4 suppression prevented the rise in SFXN1 expression brought on by apelin-13

Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI

New York: Springer (2016)