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As, la administracin de IGF-1ha demostrado ser capaz de inducir hipertrofia renal, aumento del tamao glomerular y un consecuente aumento de la tasa de filtracin glomerular, sin llegar a desarrollar glomeruloesclerosis

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transl med commun 1 , 8 (2016) (5) Gao XY, Hou F, Zhang ZP, Nuo MT, Liang H, Cang M, Wang ZG, Wang X, Xu T, Yan LY, Guo XD, Liu DJ

Methylation levels of NLRP3, TGF1, MCP-1, and TNFSF2 are significantly lower in DR patients compared to healthy individuals, suggesting that hypomethylation of these genes contributes to DR progression [66]