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3.7 Neurological diseases Lf/PBA-modified hyaluronic acid nanogels linked via disulfide bonds (Lf-DOX/PBNG) were designed for reduction-sensitive, dual-targeting glioma treatment, showing increased DOX release in high glutathione conditions, superior cytotoxicity, cellular absorption, and brain permeability compared to DOX solution and other nanogel types, as well as significantly enhanced pharmacokinetics and brain retention [140]

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