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10.1016/j.vaccine.2012.10.083 Vaccine 115 LaliberteJ.CaiY.KennyT.ZhangY.RenK.RosenthalK.et al

This appears to involve a particular enzyme complex called mitochondrial complex I

Conclusion The gut microbiome plays a vital role in maintaining the astronauts health throughout the mission

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PFIC typically causes progressive fibrogenic liver disease, leading to portal hypertension, cirrhosis, and finally to end-stage disease with liver failure requiring liver transplantation (LT) [9]