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Use of optimized recombinant episomal replication vector module to construct genetic vaccine vectors Upon identifying cells which contain an episomally maintained vector, the optimized recombinant episomal replication vector module is obtained and used to construct genetic vaccine vectors

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& Kwon, O

Curr Biol , 2020, 30: R1292R1297 Jiang X, Stockwell BR, Conrad M

Mitochondrial dysfunction plays a central role, leading to impaired oxidative phosphorylation, reduced adenosine triphosphate (ATP) generation, and increased oxidative stress, all contributing to cellular damage and death [2]

76 In recent years, the GATOR1 complex has been shown to play an important role in the pathogenesis of focal epilepsies, with DEPDC5 exhibiting a higher mutation frequency (approximately 85% of reported cases) than NPRL2 (5%) and NPRL3 (10%)