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Real-time DEXA was employed to monitor changes in bone mineral content, focusing on specific regions like the femur and L6 vertebrae

IGF-1 LR3 IGF-1 LR3 is a modified form of insulin-like growth factor-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension, designed to have reduced binding to IGF-binding proteins, which increases its free, biologically active fraction and potency

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Interestingly, IGF-I produced by the liver failed to reach bone to compensate for local IGF-I deficiency

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