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Those with more severe Crohn disease may have these problems: Abscess or infection in the intestines Anemia, a lack of red blood cells Bowel blockage Fistulas in the bladder, skin, or vagina Slow growth and sexual development in children Swelling of the joints Lack of important nutrients, such as vitamin B12 and iron Problems with maintaining a healthy weight Swelling of the bile ducts (primary sclerosing cholangitis) Skin lesions, such as pyoderma gangrenosum When to Contact a Medical Professional Contact your provider if you: Have very bad abdominal pain Cannot control your diarrhea with diet changes and drugs Have lost weight, or a child is not gaining weight Have rectal bleeding, drainage, or sores Have a fever that lasts for more than 2 or 3 days, or a fever higher than 100.4F (38C) without an illness Have nausea and vomiting that lasts for more than a day Have skin sores that do not heal Have joint pain that prevents you from doing your everyday activities Have side effects from medicines you are taking for your condition Gallery References Ananthakrishnan AN, Reguerio MD

Lack of Vitamin B12 can create anaemias

There was a 2015 Phase I human trial registered to study safety and pharmacokinetics, but published results are conspicuously missing

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While spadin effects last approximately seven hours, PE-22-28 maintains its activity for up to 23 hours

Regular screening every 1-2 years catches disease early in high-risk patientswaiting until symptoms appear often means 60-70% of kidney function is already lost