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What disease did Goethe witness during his journey through the Italian Alps

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kinact is 0.068/s 3-[3-(2,4-dichlorophenyl)propanoyl]-2-hydroxycyclohepta-2,4,6-trien-1-one - 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid - - 3-[oxalyl-amino]naphthalene-2-carboxylic acid - 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,8-dicarboxylic acid 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid 3alpha-angeloyloxypterokaurene L3 18% inhibition at 0.024 mM 3alpha-cinnamoyloxypterokaurene L3 - 3alpha-oleanolic acid - 3alpha-tigloyloxypterokaurene L3 no inhibition at 0.024 mM 3beta,16a,17-trihydroxy-olean-12-ene - - 3beta-acetoxy-17beta-hydroxy-28-norolean-12-ene - - 3beta-acetoxy-28-hydroxyolean-12-ene - - 3beta-acetoxyolean-12-en-28-acid - - 3beta-acetoxyolean-12-en-28-aldehyde - - 3beta-hydroxyolean-12-en-28-oic acid - - 4'-carboxy-3'-hydroxy-1,1'-biphenyl no inhibition of LMW-PTP isozymes, but 10% inhibition of PTP-B1 at 0.02 mM 4'-[(2-butyl-1-benzofuran-3-yl)methyl]biphenyl-4-ol - 4'-[2-(4-hydroxybutyl)-1-benzofuran-3-yl]biphenyl-4-ol - 4,4'-methylenebis(3,5,6-tribromobenzene-1,2-diol) 78.64% inhibition at 0.02 mg/ml 4,4'-methylenebis(5,6-dibromobenzene-1,2-diol) - 4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid - 4,6-bis(1,3,2-dithiarsolan-2-yl)-7-hydroxy-3H-phenoxazin-3-one i.e

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(Data points are mean SD, n = 68.) ( E ) Changes of fibrotic markers Tgfb1 , Col1a1 , and Fn1 mRNA expression levels after virus infection in Cyb5r3 fl/fl and Cyb5r3 SPCKO mice

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Chronic PM. exposure reduces the hippocampal expression of brain-derived neurotrophic factor (BDNF), inducing depression-like behaviors [246, 247]

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