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J Affect Disord (2010) 126:45862.10.1016/j.jad.2010.04.027 203 CrumpCSundquistKWinklebyMASundquistJ

In a healthy cell, ROS are necessary and have roles in cell signaling [277]

1: Lomaestro BM, Malone M (1995)

119 Research indicates that factors such as age, diet, alcohol consumption, fructose-rich intake, pharmacologic interventions and diseases, such as obesity, insulin resistance, Down syndrome, and kidney disease, contribute to the development of hyperuricemia 120,121,122,123,124 (Fig