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Description

Brain, brown fat, and skeletal muscle are among the tissues that contain deiodinase type 2 (DIO2), an enzyme that converts T4 to T3 on a local level

& Bonifacino, J

J Clin Invest (2003) 111:170313.10.1172/JCI16921 183 BeetonCWulffHStandiferNEAzamPMullenKMPenningtonMWet alKv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

This opens up possibilities for lifestyle interventions to modulate GSH levels and support brain health: ketogenic diets, by generating ketone bodies like -hydroxybutyrate, activate astrocytic Nrf2 signaling to upregulate glutamate cysteine ligase and enhance GSH synthesis