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Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

Ashford, J

In addition, research had reported that dihydrosphingosine (dhSph) was significantly elevated in the stratum corneum of the lesional skin in atopic dermatitis and was associated with skin barrier function, disease severity, and local cytokine levels (49)

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