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Jan 24 2020;19(1):8

In addition, ROS stabilize and enhance hypoxia-inducible factor-1 (HIF-1), the oxygen-sensitive subunit of the HIF-1 transcription factor, by inhibiting prolyl hydroxylasemediated degradation under both hypoxic and inflammatory conditions

Your skin will tell you the rest

These resistance mechanisms are not isolated

doi: 10.1292/jvms.65.237 53

The study examines the impact of mood-stabilizing medications, including lithium, valproate (VPA), carbamazepine (CBZ), and lamotrigine (LTG), on dendritic growth and synaptic protein expression in primary hippocampal neurons