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This compound specifically inhibits the expression of DHODH, reduces the mitochondrial cristae structure, and effectively triggers ferroptosis in multiple cancer cell lines

494 DMD is a rare genetic muscle disorder caused by mutations in the dystrophin gene, leading to the absence of the dystrophin protein

PTPMT1 knockout impairs the mitochondrial metabolism of CD8 + T cells and promotes melanoma growth by increasing CD8 + T cell fatigue and malfunction [82]

Furthermore, the safety and the toxicological profile of the compound are commented, together with its stability issues

[Abstract]2024 Sep 18;142(Pt B):113177