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Statistical analysis The SAS software was used for the ANOVA for the data

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(Reference DerSimonian and Kacker24) Furthermore, between-study heterogeneity was measured using the I 2 statistic and Cochranes Q test

Despite the difference in tCho at 3 months, we found no significant group differences in tNAA, tCr, Glx, and mI at the 3- and 6 month timepoint in comparison to OI

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Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex Glycyl-L-histidyl-L-lysine-Cu2+