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Nature 583 , 282285 (2020)

Stern Warning: Interfering with your immune system is perilous

The varieties of consequent enzymatic dysfunction resulting from these mutations include impaired binding of substrate and cofactor to the isozyme, blocked formation of a functional isozyme (deletion, nonsense mutation, or splice-junction alterations), and an unstable isozyme resulting in DHT deficiency due to a decreased conversion of testosterone to DHT (5)