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Endogenously synthesized n-3 polyunsaturated fatty acids in pregnant fat-1 mice decreases mammary cancer risk of female offspring by regulating expression of long noncoding RNAs

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Additionally, LOXs (e.g., ALOX15) directly oxidize PUFAs into lipid hydroperoxides (PUFA-OOH), accelerating ferroptosis execution, a process that can be pharmacologically inhibited by LOX blockers like zileuton or mitigated through structural PUFA modifications such as bis-allylic deuteration 24

S-adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes

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