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474 Several other meta-analyses published in 2025 examining various combinations of randomized controlled trials have had similar findings: colchicine reduced major adverse cardiovascular events risk without reducing mortality or increasing serious side effects in patients with established cardiovascular disease

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One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone

This imbalance primarily arises from excessive production of reactive oxygen species (ROS) or insufficient antioxidant defenses

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