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Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs

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It is converted to 4-coumaroyl-CoA, via phenylalanine ammonia-lysate, to cinnamate-4-hydroxylase and 4-coumaroyl-CoA-ligase

However, long-term BG00011 exposure induced acute exacerbations and inflammation, leading to reduced survival rates, and the drug was ultimately discontinued from clinical development ( Given these setbacks in novel drug development, alternative strategies such as drug repurposing have gained traction in IPF research

In vascular smooth muscle cells, PKC activation has been shown to modulate growth rate, DNA synthesis and growth factor receptor turnover

thus, DFMO alone could not achieve a good anticancer effect, and the combination of DFMO with polyamine transport inhibitors may be a more promising treatment strategy