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To incorporate GHK-Cu serum with microneedling safely and effectively, preparation is essential

For instance, a size-dependent study of surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles demonstrated that particles with the smallest size (60 nm) exhibited the highest brain accumulation compared with larger particles, suggesting that smaller nanoparticles traverse the BBB more efficiently than larger particles (Meng et al., 2022)

Meanwhile, the pro-inflammatory state, a result of local oxidative stress, stimulates many cytokines, such as IL-1 and TNF-

The blood-brain barrier (BBB) is an important physiological barrier of the CNS, composed of cerebral capillary endothelial cells, tight junctions, basement membranes and pericytes