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Sapolsky RM, Romero LM, Munck AU

It is interesting to note that immune cells like microglia and macrophages shift from oxidative phosphorylation (typical of M2 type phenotype), which corresponds to an inactive state, to aerobic glycolysis (typical of M1 type phenotype), which corresponds to a proinflammatory state [41,42]

Concurrently, it activates mTOR to enhance glycolysis and IL-2 autocrine signaling, synergizing with butyrate for robust antigen-specific T cell expansion (108)

doi: 10.3389/fendo.2023.1226687 60 DabiYEbangaLFavierAKolanskaKPucharAJayotAet al

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