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Thus, oxidative stress can lead to both organ-specific and pathway-specific toxicity without macromolecular damage (157)

Digoxin toxicity manifests gastrointestinal symptoms such as nausea and vomiting, neurologic disturbances, and life-threatening arrhythmias (11)(21)(22)

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Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism