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Previous studies have found that ACSL4 catalyzes the activation of AA to AA-CoA, which can be utilized to generate 5-hydroxyeicosatetraenoic acid (5-HETE) by lipoxygenase (LOX), thus inducing ferroptosis via 5-HETE-mediated lipotoxicity [135]

This indicates that while C-PC alone effectively targets resistant U87-EGFRvIII cells, it does not overcome CDDP resistance

81,120 Given the fact that poor water solubility and unstability of erastin, a metabolically stable erastin analogue, imidazole ketone erastin (IKE), has been developed

A ) and B ) Schematic diagram and workflow of Localis-REX coupled to BONCAT assay

MYB proto-oncogene, transcription factor (MYB)-mediated expression of cysteine dioxygenase type 1 (CDO1), an enzyme that converts cysteine to taurine by catalyzing the oxidation of cysteine to sulfinic acid, can promote erastin-induced death in gastric cancer cells, 89 indicating that non-GSH-dependent cysteine metabolism is also involved in controlling ferroptosis

What are CJC-1295 ipamorelin dosage and results