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circRNA and Ferroptosis Advanced research approaches on lincRNAs have provided guidance for perspective studies on other lncRNAs, such as circRNAs, which are RNAs that are formed with covalently closed continuous loops

LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition

At the 3 end of the gene, alternative splicing gives rise to at least three subsets of RNA transcripts, each encoding three distinct carboxy-terminal portions of the unique E-domain extension-peptide (E-peptide) as well as the 3-untranslated region (3UTR) (17,25,3136)

FIGURE 2 Epigenetic modifications in key genes related to stress and immunity, such as nuclear receptor subfamily three group C member 1 (NR3C1), TNF, and nuclear factor kappa B (NF-B), modulate both the negative feedback of the HPA axis and inflammatory pathways mediated by NF-B, suggesting a link between endocrine dysregulation and immune activation (Palma-Gudiel et al., 2021)

Nrf2is a key factor in the control of the expression of genes involved in the regulation of oxidative stress, via the enhanced production of cellular antioxidants

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