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For the tumor cell lines U87 and T98G, both the combined and individual drug treatments significantly inhibited energy metabolism, with the combined treatment showing the strongest inhibitory effect (Fig

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For example, a growing body of evidence indicates that Mn disrupts Fe homeostasis 310 , for instance, by downregulating the expression of amyloid precursor protein and H-ferritin, leading to impaired iron metabolism and increased neurotoxic oxidative stress 311

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