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NaBPC157 significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 hour bile duct and hepatic artery ligation, 48 hour restraint stress, and CCl 4 treatment (1 ml/kg i.p., sacrifice 48 hours thereafter)

Melatonin itself is released by many, if not all mitochondria-containing cells, and exhibits significant antioxidant, anti-apoptotic, anti-excitotoxic (NMDA antagonist), and anti-inflammatory effects both in vitro and in vivo [26, 136]

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy

(2022) 378:eabm3233

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