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The significant downregulation of essential energy metabolites such as AMP, ADP, and NADP indicates compromised energy metabolism, while the attenuation of antioxidant metabolites like glutathione suggests that the oxidative stress generated by these antibiotics may overwhelm bacterial antioxidant defense mechanisms

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doi: 10.1016/j.jad.2023.02.078 230 ZhanG.YangN.LiS.HuangN.FangX.ZhangJ.et al

The plasma samples were collected, frozen at 80 C, and stored until analysis

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