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GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24

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For instance, DTCs from indolent prostate cancer secrete acidic and cysteine-rich secretory proteins to indirectly trigger the activation of MSC-derived BMP7, which in turn activates dormancy-related signaling pathways in DTCs, such as p38, MAPK and p21 [41]