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This suggests that in addition to CLK/CYC, other transcription factors contribute to the regulation of these genes in old flies

Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia AJ, Koong AC , Diehn M, Le QT

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B12 deficiency can take 6-12+ months to overcome