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Thioredoxin ( n =41), TxNIP ( n =39), GST ( n =43) and MnSOD ( n =20) all showed significant increases in expression levels after anthracycline-based chemotherapy ( P =0.00000002, P =0.006, P =0.023 and P =0.048, respectively) (Figure 5)

Hepatocytes can also undergo necroptosis, a regulated process of necrotic cell death in NAFLD and NASH [95, 96]

Consistency is crucial for seeing results

First the two experimental replicates were merged on the basis of protein reference IDs to identify high confidence targets for each erastin analog in both cell lines

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Although it is not always obvious why so many contradictory results are being reported, it might be useful to focus on the clinically relevant aspects