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A drugs last Orange Book patent may expire in year 12 while NCE or ODE exclusivity continues through year 15

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Oocysts were detected after incubation with a Rhodamine Red-X goat anti-mouse IgG (H+L) secondary antibody (Invitrogen)

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In the presence of an alternative tight binding ligand ( e.g., oxalate, a bidentate ligand, X ), we can imagine the simple equilibrium below: Alternatively, X could be imagined displacing water, leading to the equilibrium: Provided X binds more tightly than the chelate, the equilibrium will lie on the right-hand side of the equation

Hajiboland R, Panda CK, Lastochkina O, Gavassi MA, Habermann G, Pereira JF