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Individuals taking medications for diabetes, thyroid disorders, or other metabolic conditions should use AOD-9604 only under medical supervision with appropriate monitoring

It directly neutralizes reactive oxygen species (ROS) generated by the mitochondrial respiratory chain, regenerates oxidized vitamins C and E, and catalyzes the conjugation of xenobiotics via glutathione S-transferase (phase II detoxification)

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Adequate levels of Vitamin B12 contribute to the efficient functioning of these immune cells

In laboratory studies, it is sometimes used alongside other metabolic or mitochondrial research agents, depending on experimental design

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)