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The pathological process involves multiple mechanisms such as oxidative stress, inflammatory response and vascular abnormalities, which ultimately lead to loss of central vision

However, for the 2021 validation cohort expanded the sample size for more statistical confidence while attempting to control for unknown variables

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10.1007/s00109-005-0715-8 James MJ, Gibson RA, Cleland LG: Dietary polyunsaturated fatty acids and inflammatory mediator production

Specifically, Tyr showed a significant change (VIP score = 1.244, correlation P-value: 9.58E-09)