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The latter, through the formation of ROS, cause direct membrane damage triggering the genesis of a vicious circle inflammatory process that underlies the pathogenesis of AD (17)

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This is particularly important as aldose reductase activity is a major contributor to microvascular complications in DR, including retinal damage

BMC Bioinformatics 19 , 404 (2018)

Previous evidence collectively implies that the PDE/cAMP/PKA/CREB/BDNF pathway could be intimately involved in resisting ischemic injury