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Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway

Based on a previous work, 30 mg/kg was considered the dose sufficient to achieve a C max comparable to the L-carnitine concentration used in vitro (1 mM) 41

The translation of preclinical discoveries into current investigational therapeutics, novel therapeutic categories such as antisense oligonucleotides and stem cell transplantation, as well as future horizons harnessing the power of artificial intelligence in drug development and clinical trials are discussed

doi:10.1016/j.nutres.2017.07.008

Insights into the mechanism of carnitine recognition

8 However, many patients previously diagnosed with EDS-HT/JHS will not meet the stricter set of criteria for hEDS under the new nosology