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In fact, SOD significantly reduces the expression of TGF-beta1 while an increase of TGF-beta1 expression is associated with fibrotic diseases ( Direct murine skin-exposure to various oxidative stresses requires a high antioxidant capacity to maintain a low oxidant balance (Figure 2B)

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Following the treatments the cells were subjected to caspase 3/7, 8, and 9 activities measurement with Caspase-Glo assay kits (Promega, Madison, WI, USA) according to the manufacturers protocol

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Mn impact on the brain and its association with neurodegenerative diseases such as Alzheimers and Parkinsons is well-recognized [6]