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Muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage ( cholinergic crisis ) An important complication that can arise is obstruction of the airway by bronchial secretions Pharmacokinetics: IV and IM administration Rapid renal excretion, resulting in a short duration of action of 5-10 mins Major drug Interactions: Care should be given when administering this drug to patients with symptoms of myasthenic weakness who are also on anticholinesterase drugs Since symptoms of anticholinesterase overdose (cholinergic crisis) may mimic underdosage (myasthenic weakness), their condition may be worsened by the use of this drug Figure 2

ROS oxidize DCF to the fluorescent product fluorescein

Lin et al., 2024)

Reactive oxygen species (ROS) such as hydrogen peroxide and alkylperoxides produced by various metabolic processes can cause irreversible oxidative damage to the cell if they are not rapidly detoxified by antioxidant defenses

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