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We found a significant reduction in hippocampal NAA and an increase in mI in RRMS in comparison to age and sex-matched healthy individuals in the cross-sectional analyses

ALDH2 deficiency did not affect liver disease progression but increased HCC risk in cirrhotic HBV patients with AUD ( Additionally, reduced ALDH2 expression in liver cancer tissues correlates with increased tumor growth, migration, and poor prognosis, and this deficiency disrupts cellular redox balance and metastatic potential ( Accumulation of high levels of HBsAg adds another layer of oncogenic stress by inducing ER stress

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Under aerobic conditions, mitochondria oxidize NADH to NAD + and convert pyruvate to CO 2 and H 2 O, so that lactate is not formed

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The major metabolite in humans and rodents, hydroxy-ITZ (OH-ITZ), is produced by cytochrome P450 (CYP) 3A4